3. MEASUREMENT OF INR VALUES THROUGH COAGUCHEK XS POC DEVICE IN PATIENTS ON ANTICOAGULANT MONOTHERAPY

Authors:

Dinkova A., Vladimirova-Kitova L.*, Deneva T.**

Medical University – Plovdiv, Faculty of Dental Medicine, Department of Oral Surgery

* Medical University – Plovdiv, Clinic of Cardiology

** Medical University – Plovdiv, Department of Clinical Laboratory

Anticoagulant therapy is widely used for treatment and prevention of arterial and venous thrombosis. The most widely used oral anticoagulant in Bulgaria is Sintrom (acenocoumarol). As other vitamin K antagonists it requires frequent laboratory monitoring of PT/INR for dose adjustment. To facilitate this control in the early 90s were introduced POC (Point of care) devices for INR/PT measurement at the moment. Some earlier studies have shown statistically significant differences between values from laboratory and POC meters, because of which the accuracy of these meters remain still controversial.

Aim of this study was to evaluate the results of INR on the CoaguChek XS meter relative to laboratory results.

Material and methods: INR values of 40 patients, receiving acenocumarol (Sintrom) were measured by laboratory coagulometer CS Sysmex 2000i and by CoaguChek XS POC analyser. The accuracy of the CoaguChek XS was determined by comparing the INR value with laboratory by linear regression analysis. Bland-Altman plot was used to assess the agreement between the monitor and laboratory values of INR.

Results: An excellent correlation between INR values obtained by CoaguChek XS and the laboratory method was found. Bland Altman plot demonstrated great agreement between INR values obtained by the two methods.

Conclusion: CoaguChek XS analyzer is precise and reliable devise for INR measurement, compared with laboratory results. Therefore, it has the potential to become part of the daily practice of physicians, including dentists treating patients receiving VKA.

Keywords: coagulation analyzer, point-of-care testing, prothrombin time, INR

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