AZATRIL® IN DENTAL MEDICINE

Actavis company’s presentation

Macrolides are a group of similar substances, characterized by a macrocyclic lactone ring, usually containing from 14 to 16 atoms.

The group of new, advanced macrolides include:

• Clarithromycin
• Azithromycin – Azatril®
• Telithromycin
• Josamycin

Azithromycin is representative of a relatively new class of macrolide – azalides that shows the optimum antibacterial spectrum to:

• G (+) microorganisms
• G (-) microorganisms
• Atypical agents of tissue and intracellular infections
• Anaerobic microorganisms – Fusobacteria

Azatril® Key Benefits
In the pH range of the stomach Azatril® is 300 times more stable than the prototype macrolide Erythromycin.

High tissue concentrations that persist for a long time (5 to 7 days) after stopping the drug mainly in infected tissues due to prolonged half-life and phagocytic directional transmission.

Indication:

• Infections of the upper respiratory tract
• Infections of the lower respiratory tract
• Infections of skin and soft tissue
• Sexually transmitted infections
• Odontogenic infections:
  – odontogenic sinusitis
  – periodontitis

Clinical studies

The penetration of Azatril® in normal and inflamed gingival tissue can be used to treat chronic inflammatory periodontal diseases as well as for prophylaxis.

Azatril® suspension is particularly suitable for use in pediatric patients because of its advantages:

• Once-daily dosing and short course of treatment
• Pleasant banana flavor

Why Azatril® unique?

• In mild to moderate infections
• The only azithromycin in Bulgaria with 5 dosage forms
• 4 of them are manufactured in Bulgaria
• Immunomodulating effect:
• Guaranteed success in empirical therapy
• Show in odontogenic infections